Nanoscale structural alteration of lung collagen in response to strain and bleomycin injury

Nanoscale structural alteration of lung collagen in response to strain and bleomycin injury

Abstract The link between the structural organization of the fibrillar components of lung extracellular matrix (ECM), local tissue stiffness and global viscoelastic behaviour is not known. Here we investigated the effect of injurious mechanical ventilation on the local lung tissue stiffness using 4D...

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Main Authors: Richard T. Deyhle, Robin Krüger, Luca Fardin, Irma Mahmutovic Persson, Jose Luis Cercos-Pita, Gaetano Perchiazzi, Andreas Menzel, Martin Bech, Lars E. Olsson, Sam Bayat
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ventilator-induced lung injury
X-ray microscopy
Small-angle x-ray scattering
Collagen
Elastin
Online Access:https://doi.org/10.1038/s41598-025-07218-9
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https://doi.org/10.1038/s41598-025-07218-9

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