Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex

The concept that dimeric protein complexes in synapses can sequentially replace their subunits has been a cornerstone of Francis Crick’s 1984 hypothesis, explaining how long-term memories could be maintained in the face of short protein lifetimes. However, it is unknown whether the subunits of prote...

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Bibliographic Details
Main Authors: Katie Morris, Edita Bulovaite, Takeshi Kaizuka, Sebastian Schnorrenberg, Candace T Adams, Noboru Komiyama, Lorena Mendive-Tapia, Seth GN Grant, Mathew H Horrocks
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
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Online Access:https://elifesciences.org/articles/99303
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