Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex
The concept that dimeric protein complexes in synapses can sequentially replace their subunits has been a cornerstone of Francis Crick’s 1984 hypothesis, explaining how long-term memories could be maintained in the face of short protein lifetimes. However, it is unknown whether the subunits of prote...
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Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2024-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/99303 |
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