Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth

Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth

Abstract Nucleos(t)ides are essential for DNA/RNA synthesis, energy metabolism, and signaling, yet their roles in placental development remain poorly understood. The placenta undergoes dynamic metabolic adaptations throughout gestation to support fetal growth. This study investigates gene expression...

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Bibliographic Details
Main Authors: Mohammed Ali, Mariia Adler, Antonin Libra, Ivan Vokral, Rona Karahoda, Eva Cifkova, Miroslav Lisa, Jakub Tomek, Magdalena Novotna, Frantisek Staud, Lukas Cerveny
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Nucleotide and nucleoside metabolism in placenta
Adenosine receptors
Preterm birth
Nucleoside transporters
Placental gene expression
Cytotrophoblast and syncytiotrophoblast
Online Access:https://doi.org/10.1038/s41598-025-16183-2
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https://doi.org/10.1038/s41598-025-16183-2

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