Melatonin promoted the therapeutic potential of cisplatin in a rat model of hepatocellular carcinoma: COX-2 and MDM2/p53/miR-155 modulation associated with cytoprotection and tumour regression

Melatonin promoted the therapeutic potential of cisplatin in a rat model of hepatocellular carcinoma: COX-2 and MDM2/p53/miR-155 modulation associated with cytoprotection and tumour regression

Abstract Globally, hepatocellular carcinoma (HCC) presents a clinical and financial burden, as it is often diagnosed at a later stage. Cisplatin is one of the most commonly used chemotherapeutics for treating various types of solid tumours; however, it is a double-edged sword due to its cytotoxic ef...

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Main Authors: Asmaa Mohammed ShamsEldeen, Laila Rashed, Abbas Mohamed, Ebtehal Gamal Abdelhady, Sara Adel Hosny, Hala Hassan Mohamed, Yara Sayed Eldosouky, Mohamed Hassan Gad, Hind Awad Zafrah, Hayam Ateyya, Hend Ashour
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
HCC
Cisplatin
Melatonin
MiR-155
CD68
P53
Online Access:https://doi.org/10.1186/s43094-025-00846-y
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https://doi.org/10.1186/s43094-025-00846-y

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