Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial

Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial

BackgroundAlarmins mediate type 2 T helper cell (Th2) inflammation and serve as upstream signaling elements in allergic inflammation and autoimmune responses. The alarmin interleukin (IL)-25 binds to a multi-domain receptor consisting of IL-17RA and IL-17RB subunits, resulting in the release of Th2...

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Main Authors: Guolin Xu, Sabina Paglialunga, Xuchen Qian, Ru Ding, Kenneth Webster, Aernout van Haarst, Caroline Engel, Chin Wai Hui, Lik Hang Lam, Weimin Li, Wai Chung Wu, Scott Rasmussen, Allen Hunt, Shui-on Leung
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
interleukin-17 receptor B
interleukin-25
alarmins
autoimmune diseases
asthma
humanized antibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495540/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495540/full

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