Patients with detectable KIT p.D816V in peripheral blood are at high risk for adverse systemic events during venom immunotherapy and treatment failure

Patients with detectable KIT p.D816V in peripheral blood are at high risk for adverse systemic events during venom immunotherapy and treatment failure

Abstract Background Recent studies have highlighted the importance of routine screening for the somatic missense KIT p.D816V variant in peripheral blood leukocytes (PBL), and its association with severe sting anaphylaxis. Our study aimed to evaluate the clinical relevance of KIT p.D816V detected in...

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Bibliographic Details
Main Authors: Ajda Demšar Luzar, Jakob Otorepec, Mitja Košnik, Peter Kopač, Julij Šelb, Peter Korošec, Matija Rijavec
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Clinical and Translational Allergy
Subjects:
clonal mast cell disease
Hymenoptera venom allergy
KIT p.D816V variant
peripheral blood leukocytes
venom immunotherapy
Online Access:https://doi.org/10.1002/clt2.70019
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