Expression of the BCR-ABL1 Gene in Patients with Chronic Myeloproliferative Diseases with Signs of Progression

Expression of the BCR-ABL1 Gene in Patients with Chronic Myeloproliferative Diseases with Signs of Progression

Background. The V617F mutation of JAK2 is known to manifest in Ph-negative chronic myeloproliferative diseases (cMPD), such as polycythemia vera, thrombocythemia, and myelofibrosis. These diseases not infrequently advance into more aggressive forms up to acute leukemia. As the progression mechanism...

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Main Authors: LA Kesaeva, EN Misyurina, DS Mar’in, EI Zhelnova, AYu Bulanov, AE Misyurina, AA Krutov, IN Soldatova, SS Zborovskii, VA Misyurin, VV Tikhonova, YuP Finashutina, ON Solopova, NA Lyzhko, AE Bespalova, NN Kasatkina, AV Ponomarev, MA Lysenko, AV Misyurin
Format: Article
Language:Russian
Published: Practical Medicine Publishing House 2018-10-01
Series:Клиническая онкогематология
Subjects:
JAK2 V617F
BCR-ABL1
V(D)J recombinase
t(9;22)(q34;q11)
polycythemia vera
essential thrombocythemia
myelofibrosis
chronic myeloid leukemia
Online Access:http://bloodjournal.ru/wp-content/uploads/2018/09/10-1.pdf
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