The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update
The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumo...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.268 |
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| _version_ | 1841524404830339072 |
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| author | Mirna M Maarabouni Gwyn T Williams |
| author_facet | Mirna M Maarabouni Gwyn T Williams |
| author_sort | Mirna M Maarabouni |
| collection | DOAJ |
| description | The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene. |
| format | Article |
| id | doaj-art-96aff7f77cec4b0bb0bdeaa2d099295c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-96aff7f77cec4b0bb0bdeaa2d099295c2025-02-03T05:53:23ZengWileyThe Scientific World Journal1537-744X2006-01-0161705171210.1100/tsw.2006.268The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research UpdateMirna M Maarabouni0Gwyn T Williams1Institute for Science and Technology in Medicine, Keele University, Keele, Staffs, ST5 5BG, UKInstitute for Science and Technology in Medicine, Keele University, Keele, Staffs, ST5 5BG, UKThe candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.http://dx.doi.org/10.1100/tsw.2006.268 |
| spellingShingle | Mirna M Maarabouni Gwyn T Williams The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update The Scientific World Journal |
| title | The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update |
| title_full | The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update |
| title_fullStr | The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update |
| title_full_unstemmed | The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update |
| title_short | The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update |
| title_sort | antiapoptotic rbm5 luca 15 h37 gene and its role in apoptosis and human cancer research update |
| url | http://dx.doi.org/10.1100/tsw.2006.268 |
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