Simultaneous targeting and suppression of heat shock protein 60 to overcome heat resistance and induce mitochondrial death of tumor cells in photothermal immunotherapy

Simultaneous targeting and suppression of heat shock protein 60 to overcome heat resistance and induce mitochondrial death of tumor cells in photothermal immunotherapy

As the most aggressive and metastatic subtype of breast cancer, clinical demands of triple negative breast cancer (TNBC) have far not been met. Heat shock protein 60 (HSP60) is over expressed in tumor cells and impair the efficacy of photothermal therapy. In this work, a conjugate composed of self-d...

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Bibliographic Details
Main Authors: Yiling Meng, Tao Wen, Xuanxin Liu, Aiyun Yang, Jie Meng, Jian Liu, Jianhua Wang, Haiyan Xu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials Today Bio
Subjects:
HSP60
Gold nanorods
Mitochondrial targeting
Photothermal therapy
Triple-negative breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424003430
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