Analysis of imaging signatures in 18F-DOPA PET of glioblastoma treated with dose-escalated radiotherapy

Analysis of imaging signatures in 18F-DOPA PET of glioblastoma treated with dose-escalated radiotherapy

Background/objectives18F-DOPA is an amino acid radiotracer with high uptake in glioblastoma and low uptake in normal brain. Patients underwent pre-radiation and post-radiation 18F-DOPA PET scans on a prospective clinical trial. This analysis investigates quantitative image features correlated with p...

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Main Authors: Jing Qian, Deanna H. Pafundi, William G. Breen, Paul D. Brown, Christopher H. Hunt, Mark S. Jacobson, Derek R. Johnson, Timothy J. Kaufmann, Bradley J. Kemp, Sani H. Kizilbash, Val J. Lowe, Michael W. Ruff, Jann N. Sarkaria, Joon H. Uhm, Mark J. Zakhary, Maasa H. Seaberg, Hok Seum Wan Chan Tseung, Elizabeth S. Yan, Yan Zhang, Nadia N. Laack, Debra H. Brinkmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
radiotherapy
18 F-DOPA PET
treatment response
quantitative imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1623313/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1623313/full

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