The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR‐99a/mTOR‐Mediated Autophagy and Apoptosis

The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR‐99a/mTOR‐Mediated Autophagy and Apoptosis

Abstract The mammalian target of rapamycin (mTOR) is a critical signaling hub for sustaining cancer survival. Targeting mTOR and inducing autophagic cell death downstream of it represent promising therapeutic strategies for cancer prevention. A US Food and Drug Administration‐approved drug library c...

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Main Authors: Hui‐Fang Hu, Jia‐Ying Fu, Lei Han, Gui‐Bin Gao, Wei‐Xia Zhang, Si‐Ming Yu, Nan Li, Yang‐Jia Li, Yi‐Fan Lu, Xiao‐Feng Ding, Yun‐Long Pan, Yang Wang, Qing‐Yu He
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
5‐FU
autophagy
aripiprazole
LAMP2a
mTOR
Online Access:https://doi.org/10.1002/advs.202409498
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https://doi.org/10.1002/advs.202409498

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