Identifying propionate metabolism-related genes as biomarkers of sepsis development and therapeutic targets

Identifying propionate metabolism-related genes as biomarkers of sepsis development and therapeutic targets

Abstract The treatment of sepsis is challenging due to unclear mechanisms. Propionate is increasingly seen as critical to sepsis pathophysiology by bridging gut microbiota and immunity, but the mechanisms remain unclear. Our study analysed differences in propionate metabolism in peripheral blood mon...

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Bibliographic Details
Main Authors: Lechen Yang, Weifeng Shang, Dongjie Chen, Hang Qian, Sheng Zhang, Xiaojun Pan, Sisi Huang, Jiao Liu, Dechang Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sepsis
Propionate metabolism
Plasma cells
Machine learning
Diagnostic modeling
Online Access:https://doi.org/10.1038/s41598-025-06463-2
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https://doi.org/10.1038/s41598-025-06463-2

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