An Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma Therapy
Abstract The glaucoma treatment paradigm is in evolution. The topical medications-first approach is limited by significant barriers such as high rates of nonadherence and side effects including ocular surface disease. The era of interventional glaucoma has seen the development of selective laser tra...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-11-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-024-01073-z |
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| author | J. Morgan Micheletti Mitchell Shultz Inder Paul Singh Thomas W. Samuelson |
| author_facet | J. Morgan Micheletti Mitchell Shultz Inder Paul Singh Thomas W. Samuelson |
| author_sort | J. Morgan Micheletti |
| collection | DOAJ |
| description | Abstract The glaucoma treatment paradigm is in evolution. The topical medications-first approach is limited by significant barriers such as high rates of nonadherence and side effects including ocular surface disease. The era of interventional glaucoma has seen the development of selective laser trabeculoplasty (SLT), procedural pharmaceuticals, and minimally invasive glaucoma surgeries (MIGS). New and emerging data support the use of these interventional treatment modalities early in the course of glaucoma rather than reserving them for advanced or treatment-recalcitrant cases. The various treatments available represent multiple mechanisms (e.g., trabecular outflow, uveoscleral outflow, aqueous suppression) and modalities (medications, laser, incisional surgery) by which intraocular pressure (IOP) is reduced. Many patients require more than one treatment to achieve adequate IOP reduction and glaucoma control. Comprehensive IOP control—reduction of both mean IOP and IOP fluctuation—can best be achieved by targeting multiple mechanisms of IOP reduction and taking advantage of the attributes of multiple treatment modalities. |
| format | Article |
| id | doaj-art-955efa35dcd04dd8be6fa8f1793f7bb1 |
| institution | Kabale University |
| issn | 2193-8245 2193-6528 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj-art-955efa35dcd04dd8be6fa8f1793f7bb12025-01-12T12:10:41ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282024-11-01141132210.1007/s40123-024-01073-zAn Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma TherapyJ. Morgan Micheletti0Mitchell Shultz1Inder Paul Singh2Thomas W. Samuelson3Berkeley Eye CenterShultz Chang VisionEye Centers of Racine and KenoshaMinnesota Eye Consultants, University of MinnesotaAbstract The glaucoma treatment paradigm is in evolution. The topical medications-first approach is limited by significant barriers such as high rates of nonadherence and side effects including ocular surface disease. The era of interventional glaucoma has seen the development of selective laser trabeculoplasty (SLT), procedural pharmaceuticals, and minimally invasive glaucoma surgeries (MIGS). New and emerging data support the use of these interventional treatment modalities early in the course of glaucoma rather than reserving them for advanced or treatment-recalcitrant cases. The various treatments available represent multiple mechanisms (e.g., trabecular outflow, uveoscleral outflow, aqueous suppression) and modalities (medications, laser, incisional surgery) by which intraocular pressure (IOP) is reduced. Many patients require more than one treatment to achieve adequate IOP reduction and glaucoma control. Comprehensive IOP control—reduction of both mean IOP and IOP fluctuation—can best be achieved by targeting multiple mechanisms of IOP reduction and taking advantage of the attributes of multiple treatment modalities.https://doi.org/10.1007/s40123-024-01073-zModalityMechanismProcedureLaserMedicationMIGS |
| spellingShingle | J. Morgan Micheletti Mitchell Shultz Inder Paul Singh Thomas W. Samuelson An Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma Therapy Ophthalmology and Therapy Modality Mechanism Procedure Laser Medication MIGS |
| title | An Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma Therapy |
| title_full | An Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma Therapy |
| title_fullStr | An Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma Therapy |
| title_full_unstemmed | An Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma Therapy |
| title_short | An Emerging Multi-mechanism and Multi-modal Approach in Interventional Glaucoma Therapy |
| title_sort | emerging multi mechanism and multi modal approach in interventional glaucoma therapy |
| topic | Modality Mechanism Procedure Laser Medication MIGS |
| url | https://doi.org/10.1007/s40123-024-01073-z |
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