An AMP‐activated protein kinase‐PGC‐1α axis mediates metabolic plasticity in glioblastoma

An AMP‐activated protein kinase‐PGC‐1α axis mediates metabolic plasticity in glioblastoma

Abstract Glioblastoma, the most frequent primary malignant brain tumour in adults, is characterised by profound yet dynamic hypoxia and nutrient depletion. To sustain survival and proliferation, tumour cells are compelled to acquire metabolic plasticity with the induction of adaptive metabolic progr...

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Main Authors: Benedikt Sauer, Jan Kueckelhaus, Nadja I. Lorenz, Süleyman Bozkurt, Dorothea Schulte, Jan‐Béla Weinem, Mohaned Benzarti, Johannes Meiser, Hans Urban, Giulia Villa, Patrick N. Harter, Christian Münch, Johannes Rieger, Joachim P. Steinbach, Dieter Henrik Heiland, Michael W. Ronellenfitsch
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Clinical and Translational Medicine
Subjects:
AMP‐activated protein kinase
glioblastoma
hypoxia
metabolic plasticity
PGC‐1α
PPARGC1A
Online Access:https://doi.org/10.1002/ctm2.70030
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https://doi.org/10.1002/ctm2.70030

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