USP5-induced deubiquitination of P4HB alleviates ER stress-mediated apoptosis in intestinal ischemia/reperfusion

USP5-induced deubiquitination of P4HB alleviates ER stress-mediated apoptosis in intestinal ischemia/reperfusion

Abstract Intestinal ischemia/reperfusion (I/R) is a severe pathophysiological process that occurs in a variety of clinical conditions and can trigger multiple life-threatening syndromes. Intestinal I/R is associated endoplasmic reticulum (ER) stress. Prolyl 4-hydroxylase subunit beta (P4HB) contribu...

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Bibliographic Details
Main Authors: Shili Ning, Peiyan Zhong, Xuzi Zhao, Yan Zhao, Fengyuan Yang, Zhao Chen, Feng Zhang, Shanshan Guo, Yuanhui Wu, Jihong Yao, Xiaofeng Tian
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
Ischemia/reperfusion
P4HB
ER-stress
Apoptosis
Deubiquitination
Online Access:https://doi.org/10.1007/s00018-025-05752-3
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