Deptor protects against myocardial ischemia-reperfusion injury by regulating the mTOR signaling and autophagy

Deptor protects against myocardial ischemia-reperfusion injury by regulating the mTOR signaling and autophagy

Abstract Deptor knockout mice were constructed by crossing Deptor Floxp3 mice with myh6 Cre mice, establishing a myocardial ischemia-reperfusion (I/R) model. Deptor knockout mice exhibited significantly increased myocardial infarction size and increased myocardial apoptosis in vivo. ELISA analysis i...

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Main Authors: Qunjun Duan, Weijun Yang, Xian Zhu, Zhanzeng Feng, Jiangwei Song, Xiaobin Xu, Minjian Kong, Jiayan Mao, Jian Shen, Yuqin Deng, Rujia Tao, Hongfei Xu, Wei Chen, Weidong Li, Aiqiang Dong, Jie Han
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02263-1
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https://doi.org/10.1038/s41420-024-02263-1

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