Eucommia ulmoides Oliver polysaccharide alleviates glucocorticoid-induced osteoporosis by stimulating bone formation via ERK/BMP-2/SMAD signaling

Eucommia ulmoides Oliver polysaccharide alleviates glucocorticoid-induced osteoporosis by stimulating bone formation via ERK/BMP-2/SMAD signaling

Abstract Osteoporosis (OP) is a metabolic disease characterized by low bone mineral mass owing to osteoblast dysfunction. Eucommia ulmoides Oliver (EuO) is a Chinese herbal medicine traditionally used to treat OP. Here, a polysaccharide purified from the EuO cortex (EuOCP3) was administered to OP mi...

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Bibliographic Details
Main Authors: Jiyu Song, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Yutong Li, Min Hu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Eucommia ulmoides Oliver
Polysaccharide
Osteoporosis
Osteoblast differentiation
ERK/BMP-2/SMAD signaling
Online Access:https://doi.org/10.1038/s41598-024-80859-4
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https://doi.org/10.1038/s41598-024-80859-4

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