Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection

Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection

ABSTRACT Gammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong infection in their hosts and are associated with cancers, including B cell lymphomas. Type I and II interferons (IFNs) are critical for the control of acute and chronic gammaherpesvirus infection. However,...

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Main Authors: Erika R. Johansen, Damon L. Schmalzriedt, Danilela Avila, Paul A. Sylvester, Cade R. Rahlf, Jordan M. Bobek, Daisy Sahoo, Bonnie N. Dittel, Vera L. Tarakanova
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
STAT1
interferon
gammaherpesvirus
chronic infection
germinal center
B cell differentiation
Online Access:https://journals.asm.org/doi/10.1128/mbio.01598-24
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https://journals.asm.org/doi/10.1128/mbio.01598-24

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