Exploring the role of oxidative stress and mitochondrial dysfunction in β-damascone-induced aneuploidy

Exploring the role of oxidative stress and mitochondrial dysfunction in β-damascone-induced aneuploidy

Abstract Background The rose ketone β-damascone (β-Dam) elicits positive results in the in vitro micronucleus (MN) assay using human lymphocytes, but shows negative outcomes in the Ames test and combined in vivo MN and comet assays. This has led to the interpretation that the in vitro MN result is a...

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Bibliographic Details
Main Authors: Tsuneo Hashizume, Satoru Munakata, Tomohiro Takahashi, Taku Watanabe
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Genes and Environment
Subjects:
Aneugenicity
β-damascone
Micronucleus formation
Mitochondrial dysfunction
Oxidative stress
Online Access:https://doi.org/10.1186/s41021-024-00319-3
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https://doi.org/10.1186/s41021-024-00319-3

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