Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide

Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide

The enterobacterial common antigen (ECA) is conserved in Gram-negative bacteria of the Enterobacterales order although its function is debated. ECA biogenesis depends on the Wzx/Wzy-dependent strategy whereby the newly synthesized lipid-linked repeat units, lipid III, are transferred across the inne...

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Main Authors: Audrey Le Bas, Bradley R. Clarke, Tanisha Teelucksingh, Micah Lee, Kamel El Omari, Andrew M. Giltrap, Stephen A. McMahon, Hui Liu, John H. Beale, Vitaliy Mykhaylyk, Ramona Duman, Neil G. Paterson, Philip N. Ward, Peter J. Harrison, Miriam Weckener, Els Pardon, Jan Steyaert, Huanting Liu, Andrew Quigley, Benjamin G. Davis, Armin Wagner, Chris Whitfield, James H. Naismith
Format: Article
Language:English
Published: The Royal Society 2025-01-01
Series:Open Biology
Subjects:
flippase
oligosaccharides
lipid III
enterobacterial common antigen
membrane protein
cell wall
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240310
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