Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure

Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure

Abstract Background Acute exposure to soman (GD), an organophosphate nerve agent (OPNA), irreversibly inhibits acetylcholinesterase (AChE), induces seizures, and could be fatal if not treated immediately. Existing medical countermeasures (MCMs- atropine, oximes, and benzodiazepines) mitigate the acu...

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Main Authors: Nyzil Massey, Suraj S. Vasanthi, Claire Holtkamp, Christina Meyer, Nikhil S. Rao, Luis G. Gimenez-Lirola, Chong Wang, Hyunmook Im, Avinash S. Bevoor, Sridhar Kannurpatti, Thimmasettappa Thippeswamy
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Neuroinflammation
Subjects:
Organophosphate nerve agents
Soman (GD)
Saracatinib
Neurotoxicity
Neuroinflammation
Neurobehavior
Online Access:https://doi.org/10.1186/s12974-025-03520-5
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https://doi.org/10.1186/s12974-025-03520-5

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