TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

Abstract In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation syndrome X‐linked (ATRX) gene is mutated leading to the conclusion that the ATRX complex represses ALT. Here, we repo...

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Main Authors: Alexandre de Nonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli
Format: Article
Language:English
Published: Springer Nature 2022-08-01
Series:EMBO Molecular Medicine
Subjects:
alternative lengthening of telomeres
ATRX
osteosarcomas
telomeres
TOP3A
Online Access:https://doi.org/10.15252/emmm.202215859
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https://doi.org/10.15252/emmm.202215859

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