Immunogenicity of differentially glycosylated Marburg virus glycoproteins expressed in mammalian and insect cells

Immunogenicity of differentially glycosylated Marburg virus glycoproteins expressed in mammalian and insect cells

Abstract Marburg virus (MARV) infection can cause severe disease, and there is no available vaccine or therapeutic method. Research into potential vaccine design is focused on the glycoprotein (GP), which mediates the adherence and invasion process of the virus. However, it is unclear whether the de...

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Main Authors: Jie Li, Shaoyan Wang, Yue Cui, Liyuan Song, Zhenwei Song, Ping Huang, Xiangyang Chi, Ting Fang, Yunzhu Dong, Ruihua Li, Pengfei Fan, Yaoxing Wang, Lei Bi, Jianmin Li, Guanying Zhang, Changming Yu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Virology Journal
Subjects:
Marburg virus
Glycoproteins
Insect cell expression system
Mammalian cell expression system
Immunogenicity
Vaccine
Online Access:https://doi.org/10.1186/s12985-025-02884-7
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https://doi.org/10.1186/s12985-025-02884-7

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