Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days
BackgroundRespiratory syncytial virus (RSV) is a major cause of severe health problems in newborns and young children. The protective role and limitations of serum maternal RSV antibodies in infants under 3 months remain controversial.MethodsA two-center prospective study from 2020 to 2023 recruited...
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Frontiers Media S.A.
2025-01-01
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| author | Shuanglian Li Shuanglian Li Chenghao Mei Chenghao Mei Sainan Chen Chenglin Wang Chenglin Wang Yelei Gao Yelei Gao Jinhua Ma Jinhua Ma Li Zhong Li Zhong Tingting Luo Tingting Luo Xin Zhao Xin Zhao Huaqin Bu Huaqin Bu Ying Lyu Ying Lyu Xiaohu Kuang Zhenxing Jia Xiaoli Wang Yuqing Wang Daiyin Tian Daiyin Tian Daiyin Tian |
| author_facet | Shuanglian Li Shuanglian Li Chenghao Mei Chenghao Mei Sainan Chen Chenglin Wang Chenglin Wang Yelei Gao Yelei Gao Jinhua Ma Jinhua Ma Li Zhong Li Zhong Tingting Luo Tingting Luo Xin Zhao Xin Zhao Huaqin Bu Huaqin Bu Ying Lyu Ying Lyu Xiaohu Kuang Zhenxing Jia Xiaoli Wang Yuqing Wang Daiyin Tian Daiyin Tian Daiyin Tian |
| author_sort | Shuanglian Li |
| collection | DOAJ |
| description | BackgroundRespiratory syncytial virus (RSV) is a major cause of severe health problems in newborns and young children. The protective role and limitations of serum maternal RSV antibodies in infants under 3 months remain controversial.MethodsA two-center prospective study from 2020 to 2023 recruited infants (n=286) admitted to the respiratory departments of two children’s hospitals in southwestern and southeastern China during RSV epidemic. These infants were hospitalized with lower respiratory tract infections (LRTI). We evaluated the relationship between serum RSV Prefusion (Pre-F), postfusion (Post-F) IgG levels, subtype neutralizing antibodies, and the incidence of RSV infection, as well as the relationship between these maternal antibodies and severity of disease. Since this prospective study only included data from RSV epidemic, we retrospectively reviewed medical records from the Children’s Hospital of Chongqing Medical University for the years 2019 to 2023 (n=3467) to analyze population characteristics during both RSV epidemic and non-epidemic periods, using the same inclusion and exclusion criteria.ResultThere were no significant differences in RSV Pre-F IgG, Post-F IgG, or RSV A or B neutralizing antibody levels between the RSV infected and non-infected groups during the epidemic. While RSV Pre-F IgG antibody was inversely correlated with disease severity, RSV Post-F IgG, and RSV A and B neutralizing antibodies did not show a similar correlation across the three illness severity categories. Additionally, there were no differences in age, gender, or illness severity distribution among hospitalized patients during epidemic and non-epidemic periods.ConclusionSerum maternal antibody levels offer insufficient protection against RSV-associated LRTI in hospitalized infants aged 28 to 90 days. |
| format | Article |
| id | doaj-art-93e14457be0d49e7bb28b7a0d2d70ae3 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-93e14457be0d49e7bb28b7a0d2d70ae32025-01-07T06:40:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14376161437616Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 daysShuanglian Li0Shuanglian Li1Chenghao Mei2Chenghao Mei3Sainan Chen4Chenglin Wang5Chenglin Wang6Yelei Gao7Yelei Gao8Jinhua Ma9Jinhua Ma10Li Zhong11Li Zhong12Tingting Luo13Tingting Luo14Xin Zhao15Xin Zhao16Huaqin Bu17Huaqin Bu18Ying Lyu19Ying Lyu20Xiaohu Kuang21Zhenxing Jia22Xiaoli Wang23Yuqing Wang24Daiyin Tian25Daiyin Tian26Daiyin Tian27Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Soochow, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Yibin Hospital Affiliated to Children’s Hospital of Chongqing Medical University, Yibin, ChinaDepartment of Respiratory Medicine, Yibin Hospital Affiliated to Children’s Hospital of Chongqing Medical University, Yibin, ChinaDepartment of Respiratory Medicine, Yibin Hospital Affiliated to Children’s Hospital of Chongqing Medical University, Yibin, ChinaDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Soochow, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Child Rare Diseases in Infection and Immunity. Children's Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Yibin Hospital Affiliated to Children’s Hospital of Chongqing Medical University, Yibin, ChinaBackgroundRespiratory syncytial virus (RSV) is a major cause of severe health problems in newborns and young children. The protective role and limitations of serum maternal RSV antibodies in infants under 3 months remain controversial.MethodsA two-center prospective study from 2020 to 2023 recruited infants (n=286) admitted to the respiratory departments of two children’s hospitals in southwestern and southeastern China during RSV epidemic. These infants were hospitalized with lower respiratory tract infections (LRTI). We evaluated the relationship between serum RSV Prefusion (Pre-F), postfusion (Post-F) IgG levels, subtype neutralizing antibodies, and the incidence of RSV infection, as well as the relationship between these maternal antibodies and severity of disease. Since this prospective study only included data from RSV epidemic, we retrospectively reviewed medical records from the Children’s Hospital of Chongqing Medical University for the years 2019 to 2023 (n=3467) to analyze population characteristics during both RSV epidemic and non-epidemic periods, using the same inclusion and exclusion criteria.ResultThere were no significant differences in RSV Pre-F IgG, Post-F IgG, or RSV A or B neutralizing antibody levels between the RSV infected and non-infected groups during the epidemic. While RSV Pre-F IgG antibody was inversely correlated with disease severity, RSV Post-F IgG, and RSV A and B neutralizing antibodies did not show a similar correlation across the three illness severity categories. Additionally, there were no differences in age, gender, or illness severity distribution among hospitalized patients during epidemic and non-epidemic periods.ConclusionSerum maternal antibody levels offer insufficient protection against RSV-associated LRTI in hospitalized infants aged 28 to 90 days.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1437616/fullRSVPre-FPost-Fneutralizing antibodymaternal antibodyinfants |
| spellingShingle | Shuanglian Li Shuanglian Li Chenghao Mei Chenghao Mei Sainan Chen Chenglin Wang Chenglin Wang Yelei Gao Yelei Gao Jinhua Ma Jinhua Ma Li Zhong Li Zhong Tingting Luo Tingting Luo Xin Zhao Xin Zhao Huaqin Bu Huaqin Bu Ying Lyu Ying Lyu Xiaohu Kuang Zhenxing Jia Xiaoli Wang Yuqing Wang Daiyin Tian Daiyin Tian Daiyin Tian Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days Frontiers in Immunology RSV Pre-F Post-F neutralizing antibody maternal antibody infants |
| title | Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days |
| title_full | Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days |
| title_fullStr | Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days |
| title_full_unstemmed | Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days |
| title_short | Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days |
| title_sort | protective or limited maternal antibodies and rsv associated lower respiratory tract infection in hospitalized infants aged 28 90 days |
| topic | RSV Pre-F Post-F neutralizing antibody maternal antibody infants |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1437616/full |
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