Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy

Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy

Immunotherapy resistance remains a substantial barrier to improving treatment outcomes for patients with lung adenocarcinoma (LUAD). Identifying effective immunotherapy target is crucial for enhancing therapeutic efficacy in LUAD. Through database analysis, we discovered that ADP ribosylhydrolase-li...

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Main Authors: Rui Cai, Meng Wang, Mengting Pan, Zhiwu Zhang, Qiang Jia, Longbao Feng, Zhongjian Yu, Lu Liu, Tongyu Zhu, Silin Cai, Han Tian, Jiangyu Zhang, Rui Guo, Yanfang Zheng
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
ADP ribosylhydrolase-like 1 (ADPRHL1
ARH2)
Lung adenocarcinoma (LUAD)
M2 macrophages
Necroptosis
pH/ROS-Responsive nanosystem
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003354
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