The proteomic landscape of trophoblasts unravels calcium-dependent syncytialization processes and beta-chorionic gonadotropin (ß-hCG) production

The proteomic landscape of trophoblasts unravels calcium-dependent syncytialization processes and beta-chorionic gonadotropin (ß-hCG) production

Abstract Background The syncytiotrophoblast (STB) layer of the placenta is formed by cell fusion of cytotrophoblasts, acts as a feto-maternal barrier, is required for the production of pregnancy hormones such as chorionic gonadotropin, estradiol and progesterone and is also responsible for feto-mate...

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Main Authors: Anna-Lena Gehl, Daniel Klawitter, Ulrich Wissenbach, Marnie Cole, Christine Wesely, Heidi Löhr, Petra Weissgerber, Adela Sota, Markus R. Meyer, Claudia Fecher-Trost
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Reproductive Biology and Endocrinology
Subjects:
Placenta
Trophoblast
BeWo cells
Syncytialization
Hormone synthesis
Calcium
Online Access:https://doi.org/10.1186/s12958-025-01362-7
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https://doi.org/10.1186/s12958-025-01362-7

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