CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies

CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies

Consolidation with PD-1/PD-L1-based immune checkpoint blockade after concurrent platinum-based chemo-radiotherapy has become the new standard of care for advanced stage III unresectable non-small cell lung cancer (NSCLC) patients. In order to further improve therapy outcomes, innovative combinatoria...

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Bibliographic Details
Main Authors: Lena Gockeln, Florian Wirsdörfer, Verena Jendrossek
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CD73
adenosine
radiotherapy
radio-immunotherapy
immune-related adverse event (irAE)
immune checkpoint inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1471072/full
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