The host cells suppress the proliferation of pseudorabies virus by regulating the PI3K/Akt/mTOR pathway

The host cells suppress the proliferation of pseudorabies virus by regulating the PI3K/Akt/mTOR pathway

ABSTRACT Pseudorabies virus (PRV), a member of the alpha-herpesviruses, can infect both the nervous and reproductive systems of pigs, causing neonatal mortality and reproductive failure in sows, which incurs substantial economic losses. Neurotropism is a common characteristic of various viruses, all...

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Main Authors: Lei Xu, Qian Tao, Yang Zhang, Feng-qin Lee, Tong Xu, Li-shuang Deng, Zhi-jie Jian, Jun Zhao, Si-yuan Lai, Yuan-cheng Zhou, Ling Zhu, Zhi-wen Xu
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
pseudorabies virus
blood-brain barrier
tight junction proteins
PI3K/Akt
antiviral
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01351-24
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https://journals.asm.org/doi/10.1128/spectrum.01351-24

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