The effects of hesperidin on valproic acid-induced reduction in hippocampal neurogenesis through the antioxidant and apoptotic pathways in adult rats

The effects of hesperidin on valproic acid-induced reduction in hippocampal neurogenesis through the antioxidant and apoptotic pathways in adult rats

Abstract Treatment with valproic acid (VPA) can induce oxidative stress, leading to neuronal degeneration. Hesperidin (HSD) has an antioxidant function that can mitigate oxidative stress, thereby promoting hippocampal neurogenesis. Because brain function and memory are reliant on hippocampal neuroge...

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Main Authors: Soraya Kaewngam, Ram Prajit, Tanaporn Anosri, Kornrawee Suwannakot, Rasa Saenno, Nataya Sritawan, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Hesperidin
Valproic acid
Cell cycle arrest
Antioxidant
Apoptosis
Online Access:https://doi.org/10.1038/s41598-024-80183-x
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https://doi.org/10.1038/s41598-024-80183-x

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