Combined thermodynamic and time-resolved structural analysis of interactions between AP2 and biomimetic plasma membranes provides insights into clathrin-mediated endocytosis

Combined thermodynamic and time-resolved structural analysis of interactions between AP2 and biomimetic plasma membranes provides insights into clathrin-mediated endocytosis

Abstract Clathrin-mediated endocytosis (CME), the main mechanism for swift, selective protein uptake in eukaryotic cells, initiates with adaptor protein AP2 recruitment to the plasma membrane (PM). AP2 recognizes PM-associated PtdIns(4,5)P2 and protein cargo for internalization. Nonetheless, many as...

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Main Authors: Armando Maestro, Nathan R. Zaccai, Juan F. Gonzalez-Martinez, Pablo Sanchez-Puga, Javier Tajuelo, Miguel A. Rubio, Andreas Santamaria, Javier Carrascosa-Tejedor, Daniel Pereira, Ildefonso Marín-Montesinos, Philipp Gutfreund, Richard Campbell, Jurij Kotar, Bernard T. Kelly, Pietro Cicuta, David J. Owen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08597-5
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