Kinesin-2 autoinhibition requires elbow phosphorylation

Kinesin motor proteins facilitate microtubule-based transport by converting chemical energy into mechanical forces, but this activity is autoinhibited until cargo is loaded. Regulatory mechanisms underlying this autoinhibitory conformation are not well understood. Here, we show that a NEver in mitos...

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Bibliographic Details
Main Authors: Guanghan Chen, Zhengyang Guo, Zhiwen Zhu, Shanshan Xie, Tianhua Zhou, Guangshuo Ou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/103648
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