Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosisResearch in context

Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosisResearch in context

Summary: Background: Amyotrophic lateral sclerosis (ALS) is linked to ageing and genetic and environmental risk factors, yet underlying mechanisms are incompletely understood. We aimed to evaluate epigenetic age acceleration (EAA), i.e., DNA methylation (DNAm) age acceleration, and its association...

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Main Authors: Yue Zhao, Xiayan Li, Kai Wang, Gayatri Iyer, Stacey A. Sakowski, Lili Zhao, Samuel Teener, Kelly M. Bakulski, John F. Dou, Bryan J. Traynor, Alla Karnovsky, Stuart A. Batterman, Eva L. Feldman, Maureen A. Sartor, Stephen A. Goutman
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:EBioMedicine
Subjects:
Amyotrophic lateral sclerosis (ALS)
Epigenetic clock
Occupational risk
Immune cell proportions
Sex
Ageing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424004195
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http://www.sciencedirect.com/science/article/pii/S2352396424004195

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