Comparison of T cell response to vaccination in rheumatic patients treated with Janus kinase inhibitors and TNF inhibitors

Comparison of T cell response to vaccination in rheumatic patients treated with Janus kinase inhibitors and TNF inhibitors

Abstract Background Janus kinase inhibitors (JAKi) represent a well-established therapeutic option for the treatment of autoimmune diseases. However, there is a paucity of evidence regarding their impact on de novo immune responses to vaccinations. T cells may confer long-lasting immunity and cross-...

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Main Authors: Sebastian Hüper, Florian Eisele, Johannes Duell, Marc Schmalzing, Lea Nagler, Patrick Pascal Strunz, Matthias Froehlich, Jan Portegys, Michael Gernert
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Rheumatology
Subjects:
Janus kinase inhibitors
Vaccination
T cell response
SARS-CoV-2 vaccination
JAK- inhibitors
TH1-response
Online Access:https://doi.org/10.1186/s41927-025-00542-7
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https://doi.org/10.1186/s41927-025-00542-7

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