Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics
Conclusion: Our MR study provides evidence that genetic susceptibility to PSC is significantly associated with an increased risk of colorectal cancer in European populations. Analysis of transcriptomic data suggests that NRG1 can be used as a novel biomarker to predict patient prognosis when colorec...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/genr/5887056 |
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| _version_ | 1849327555522330624 |
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| author | Jie Jiao Honglei Wang Danping Sun Wenbin Yu |
| author_facet | Jie Jiao Honglei Wang Danping Sun Wenbin Yu |
| author_sort | Jie Jiao |
| collection | DOAJ |
| description | Conclusion: Our MR study provides evidence that genetic susceptibility to PSC is significantly associated with an increased risk of colorectal cancer in European populations. Analysis of transcriptomic data suggests that NRG1 can be used as a novel biomarker to predict patient prognosis when colorectal cancer and PSC coexist. |
| format | Article |
| id | doaj-art-92ba59cf9a4e44df9d23c944ffd96c8e |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-92ba59cf9a4e44df9d23c944ffd96c8e2025-08-20T03:47:49ZengWileyGenetics Research1469-50732025-01-01202510.1155/genr/5887056Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and BioinformaticsJie Jiao0Honglei Wang1Danping Sun2Wenbin Yu3Department of General SurgeryDepartment of General SurgeryDepartment of General SurgeryDepartment of General SurgeryConclusion: Our MR study provides evidence that genetic susceptibility to PSC is significantly associated with an increased risk of colorectal cancer in European populations. Analysis of transcriptomic data suggests that NRG1 can be used as a novel biomarker to predict patient prognosis when colorectal cancer and PSC coexist.http://dx.doi.org/10.1155/genr/5887056 |
| spellingShingle | Jie Jiao Honglei Wang Danping Sun Wenbin Yu Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics Genetics Research |
| title | Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics |
| title_full | Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics |
| title_fullStr | Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics |
| title_full_unstemmed | Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics |
| title_short | Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics |
| title_sort | investigating the causality and pathogenesis of primary sclerosing cholangitis in colorectal cancer through mendelian randomization and bioinformatics |
| url | http://dx.doi.org/10.1155/genr/5887056 |
| work_keys_str_mv | AT jiejiao investigatingthecausalityandpathogenesisofprimarysclerosingcholangitisincolorectalcancerthroughmendelianrandomizationandbioinformatics AT hongleiwang investigatingthecausalityandpathogenesisofprimarysclerosingcholangitisincolorectalcancerthroughmendelianrandomizationandbioinformatics AT danpingsun investigatingthecausalityandpathogenesisofprimarysclerosingcholangitisincolorectalcancerthroughmendelianrandomizationandbioinformatics AT wenbinyu investigatingthecausalityandpathogenesisofprimarysclerosingcholangitisincolorectalcancerthroughmendelianrandomizationandbioinformatics |