Retinal status in moderate myopia and age-related macular degeneration. Management strategies
<p> <b>L.K. Moshetova<sup>1</sup>, I.B. Alekseev<sup>1–3</sup>, I.V. Vorob’eva<sup>1,2</sup>, Yu.A. Nam<sup>3</sup></b> </p> <p> <b><sup>1</sup>Russian Medical Academy of Continuous Professional Educati...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Prime-Media
2022-05-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/9c8/9c828551f94911eedc25615c0141c652.pdf |
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| Summary: | <p>
<b>L.K. Moshetova<sup>1</sup>, I.B. Alekseev<sup>1–3</sup>, I.V. Vorob’eva<sup>1,2</sup>, Yu.A. Nam<sup>3</sup></b>
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<b><sup>1</sup>Russian Medical Academy of Continuous Professional Education, Moscow, <br>
Russian Federation</b>
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<b><sup>2</sup>S.P. Botkin City Clinical Hospital, Moscow, Russian Federation</b>
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<b><sup>3</sup>Treatment Rehabilitation Center of the Ministry of Economic Development, Moscow, <br>
Russian Federation</b>
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<i><b>Aim</b>: to assess retinal status in comorbid ocular disorders (moderate myopia and age-related macular degeneration/AMD of various stages) using modern diagnostic tools.</i>
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<i><b>Patients and Methods:</b> 48 patients (96 eyes) with moderate myopia and dry AMD were enrolled. Best-corrected visual acuity (BCVA), mean deviation/MD (characterizes mean reduction of sensitivity), pattern standard deviation/PSD (characterizes the severity of local visual field defects), central macular thickness (CMT), and axial length (AL) were measured. The macular zone was investigated by optical coherence tomography (OCT) using B scan and fundus autofluorescence (FAF) regimens.</i>
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<i><b>Results</b>: in moderate myopia associated with dry AMD (AREDS categories 1,2,3), a significant reduction in the mean BCVA (20/25) was detected in 54.2% (26 patients, 52 eyes). Retinal photosensitivity indices (MD and PSD) were also significantly reduced to 2.19 dB (р<0.001) and 2.14 dB (р<0.001), respectively. AL was significantly increased (25.11 mm, р<0.001). No significant differences in CMT values were revealed (233 mcm, p=0.123). In comorbid ocular disorders, severe defects and focuses of RPE atrophy, extensive areas of the IS/OS junction line damage, and drusen are seen among morphological abnormalities of the eye fundus. FAF identified certain pathological patterns, e.g., focal hypo- and hyperautofluorescence, hyperautofluorescent halo at the border of staphyloma, linear hypoautofluorescent bands surrounded with hyperautofluorescence, reticular pattern, patches, focal and multifocal areas of geographic atrophy.</i>
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<i><b>Conclusion</b>: our findings on visual field loss (MD, PSD) in AMD depending on stage and OCT findings in AMD are in line with the results of other authors. Meanwhile, we investigated a comorbid variant (AMD in association with moderate myopia), compared morphological and functional parameters, and addressed the relevance of FAF.</i>
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<i><b>Keywords</b>: myopia, age-related macular degeneration, optical coherence tomography, autofluorescence.</i>
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<i><b>For citation: </b>Moshetova L.K., Alekseev I.B., Vorob’eva I.V., Nam Yu.A. Retinal status in moderate myopia and age-related macular degeneration. Management strategies. Russian Journal of Clinical Ophthalmology. 2022;22(2):91–98 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-91-98.</i>
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| ISSN: | 2311-7729 2619-1571 |