Neuroprotective activity of a virus‐safe nanofiltered human platelet lysate depleted of extracellular vesicles in Parkinson's disease and traumatic brain injury models

Neuroprotective activity of a virus‐safe nanofiltered human platelet lysate depleted of extracellular vesicles in Parkinson's disease and traumatic brain injury models

Abstract Brain administration of human platelet lysates (HPL) is a potential emerging biotherapy of neurodegenerative and traumatic diseases of the central nervous system. HPLs being prepared from pooled platelet concentrates, thereby increasing viral risks, manufacturing processes should incorporat...

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Main Authors: Liling Delila, Ouada Nebie, Nhi Thao Ngoc Le, Lassina Barro, Ming‐Li Chou, Yu‐Wen Wu, Naoto Watanabe, Masayasu Takahara, Luc Buée, David Blum, David Devos, Thierry Burnouf
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Bioengineering & Translational Medicine
Subjects:
human platelet lysate
nanofiltration
neuroprotection
prion
virus
Online Access:https://doi.org/10.1002/btm2.10360
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