Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis
The main characteristics of Parkinson’s disease (PD) are the loss of dopaminergic (DA) neurons and abnormal aggregation of cytosolic proteins. However, the exact pathogenesis of PD remains unclear, with ferroptosis emerging as one of the key factors driven by iron accumulation and lipid peroxidation...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1510897/full |
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| author | Mengzhu Li Mengxuan Chen Haiyan Li Da Gao Lijun Zhao Meiling Zhu |
| author_facet | Mengzhu Li Mengxuan Chen Haiyan Li Da Gao Lijun Zhao Meiling Zhu |
| author_sort | Mengzhu Li |
| collection | DOAJ |
| description | The main characteristics of Parkinson’s disease (PD) are the loss of dopaminergic (DA) neurons and abnormal aggregation of cytosolic proteins. However, the exact pathogenesis of PD remains unclear, with ferroptosis emerging as one of the key factors driven by iron accumulation and lipid peroxidation. Glial cells, including microglia, astrocytes, and oligodendrocytes, serve as supportive cells in the central nervous system (CNS), but their abnormal activation can lead to DA neuron death and ferroptosis. This paper explores the interactions between glial cells and DA neurons, reviews the changes in glial cells during the pathological process of PD, and reports on how glial cells regulate ferroptosis in PD through iron homeostasis and lipid peroxidation. This opens up a new pathway for basic research and therapeutic strategies in Parkinson’s disease. |
| format | Article |
| id | doaj-art-923d3a858c8d43c9b4b092e381cc029f |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-923d3a858c8d43c9b4b092e381cc029f2025-01-03T06:46:56ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.15108971510897Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosisMengzhu Li0Mengxuan Chen1Haiyan Li2Da Gao3Lijun Zhao4Meiling Zhu5The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaShenzhen Clinical College of Integrated Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Clinical College of Integrated Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe main characteristics of Parkinson’s disease (PD) are the loss of dopaminergic (DA) neurons and abnormal aggregation of cytosolic proteins. However, the exact pathogenesis of PD remains unclear, with ferroptosis emerging as one of the key factors driven by iron accumulation and lipid peroxidation. Glial cells, including microglia, astrocytes, and oligodendrocytes, serve as supportive cells in the central nervous system (CNS), but their abnormal activation can lead to DA neuron death and ferroptosis. This paper explores the interactions between glial cells and DA neurons, reviews the changes in glial cells during the pathological process of PD, and reports on how glial cells regulate ferroptosis in PD through iron homeostasis and lipid peroxidation. This opens up a new pathway for basic research and therapeutic strategies in Parkinson’s disease.https://www.frontiersin.org/articles/10.3389/fcell.2024.1510897/fullParkinson’s diseaseferroptosisglia-neuron interactiondopaminergic neuronglial cellmicroglia |
| spellingShingle | Mengzhu Li Mengxuan Chen Haiyan Li Da Gao Lijun Zhao Meiling Zhu Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis Frontiers in Cell and Developmental Biology Parkinson’s disease ferroptosis glia-neuron interaction dopaminergic neuron glial cell microglia |
| title | Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis |
| title_full | Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis |
| title_fullStr | Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis |
| title_full_unstemmed | Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis |
| title_short | Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis |
| title_sort | glial cells improve parkinson s disease by modulating neuronal function and regulating neuronal ferroptosis |
| topic | Parkinson’s disease ferroptosis glia-neuron interaction dopaminergic neuron glial cell microglia |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1510897/full |
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