Lung immune incompetency after mild peritoneal sepsis and its partial restoration by type 1 interferon: a mouse model study

Lung immune incompetency after mild peritoneal sepsis and its partial restoration by type 1 interferon: a mouse model study

Abstract Background Sepsis is commonly associated with acute respiratory distress syndrome (ARDS). Although the exaggerated inflammation may damage intact lung tissues, a percentage of patients with ARDS are reportedly immunocompromised, with worse outcomes. Herein, using a murine sepsis model, time...

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Main Authors: Qiuming Meng, Fumiko Seto, Tokie Totsu, Tomoyuki Miyashita, Songfei Wu, Masahiko Bougaki, Michiko Ushio, Takahiro Hiruma, Bruce C. Trapnell, Kanji Uchida
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:Intensive Care Medicine Experimental
Subjects:
Sepsis
Acute lung injury
ARDS
Innate immunity
Immune suppression
Immune reprogramming
Online Access:https://doi.org/10.1186/s40635-024-00707-7
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https://doi.org/10.1186/s40635-024-00707-7

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