Resolvin D2/GPR 18 axis ameliorates pressure overload-induced heart failure by inhibiting pro-inflammatory macrophage polarization

Resolvin D2/GPR 18 axis ameliorates pressure overload-induced heart failure by inhibiting pro-inflammatory macrophage polarization

Accumulating evidence has revealed that chronic unresolved inflammation can cause significant tissue damage and can be a key mediator of advanced heart failure (HF). Resolvin (Rv) D2, a member of specialized pro-resolving lipid mediators (SPMs), plays a protective role in various diseases by facilit...

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Bibliographic Details
Main Authors: Zihui Zheng, Mengmeng Zhao, Yao Xu, Jishou Zhang, Shanshan Peng, Jianfang Liu, Wei Pan, Zheng Yin, Cheng Wei, Juan-Juan Qin, Jun Wan, Menglong Wang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Lipid Research
Subjects:
resolvin D2
GPR18
heart failure
pressure overload
macrophage polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524001846
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