Efficacy and safety of Mirikizumab for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials

Efficacy and safety of Mirikizumab for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials

Abstract Ulcerative colitis (UC) is a widespread incurable chronic inflammation of the colon mucosa. Currently, oral small-molecule medications targeting Janus kinase or sphingosine-1-phosphate and monoclonal antibodies to TNF-α,α4β7 integrins and Ustekinumab are the lines of treatment for UC. Up to...

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Main Authors: Mohamed A. Abu Elainein, Sama S. ElSherefy, Norhan M. Yousef, Sama M. ElKady, Nada G. Hamam, Abdullrahman Elgarawany, Darin W. Aswa, Ahmed Nour Eldin Hassan, Salma Allam
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Gastroenterology
Subjects:
Ulcerative colitis
Mirikizumab
IL-23 inhibitor
Meta-analysis
Online Access:https://doi.org/10.1186/s12876-025-03627-2
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