Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia
Sickle cell anemia is one of the best studied inherited diseases, and despite being caused by a single point mutation in the HBB gene, multiple pleiotropic effects of the abnormal hemoglobin S production range from vaso-occlusive crisis, stroke, and pulmonary hypertension to osteonecrosis and leg ul...
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Main Authors: | Mário Angelo Claudino, Kleber Yotsumoto Fertrin |
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Format: | Article |
Language: | English |
Published: |
Wiley
2012-01-01
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Series: | Anemia |
Online Access: | http://dx.doi.org/10.1155/2012/723520 |
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