Single-cell RNA sequencing of appendiceal adenocarcinoma reveals a low proportion of epithelial cells and a fibroblast enriched tumor microenvironment

Single-cell RNA sequencing of appendiceal adenocarcinoma reveals a low proportion of epithelial cells and a fibroblast enriched tumor microenvironment

Background: Appendiceal adenocarcinoma (AA) is an understudied gastrointestinal malignancy. Treatment is guided by its proximal counterpart, colorectal cancer (CRC), despite recent studies demonstrating AA’s unique mutational landscape and poor response to CRC chemotherapy. In this study, we describ...

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Main Authors: B.B. Gunes, N.J. Hornstein, M. Wang, M. Yousef, M.M. Fanaeian, A. Yousef, S. Chowdhury, M.A. Zeineddine, C. Haymaker, B. Helmink, K. Fournier, J.P. Shen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:ESMO Gastrointestinal Oncology
Subjects:
single-cell
appendiceal adenocarcinoma
tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819824000554
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http://www.sciencedirect.com/science/article/pii/S2949819824000554

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