Endothelial Cell‐Specific Prolyl Hydroxylase‐2 Deficiency Augments Angiotensin II–Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice

Endothelial Cell‐Specific Prolyl Hydroxylase‐2 Deficiency Augments Angiotensin II–Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice

Background Endothelial prolyl hydroxylase‐2 (PHD2) is essential for pulmonary remodeling and hypertension. In the present study, we investigated the role of endothelial PHD2 in angiotensin II–mediated arterial stiffness, pericyte recruitment, and cardiac fibrosis. Methods and Results Chondroitin sul...

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Bibliographic Details
Main Authors: Bo Liu, Heng Zeng, Han Su, Quinesha A. Williams, Jessie Besanson, Yingjie Chen, Jian‐Xiong Chen
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiotensin II
arterial stiffness
cardiac fibrosis
pericytes
prolyl hydroxylase‐2
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.035769
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https://www.ahajournals.org/doi/10.1161/JAHA.124.035769

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