The AβA2V paradigm: From molecular insights to therapeutic strategies in Alzheimer’s disease and primary tauopathies

The AβA2V paradigm: From molecular insights to therapeutic strategies in Alzheimer’s disease and primary tauopathies

Alzheimer’s disease, the leading cause of dementia globally, represents an unresolved clinical challenge due to its complex pathogenesis and the absence of effective treatments. Considering the multifactorial etiology of the disease, mainly characterized by the accumulation of amyloid β plaques and...

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Main Authors: Luisa Diomede, Andrea Conz, Michele Mosconi, Tatiana Stoilova, Matteo Paloni, Matteo Salvalaglio, Alfredo Cagnotto, Laura Colombo, Marcella Catania, Giuseppe Di Fede, Fabrizio Tagliavini, Mario Salmona
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
Alzheimer's disease
Amyloid-β plaques
Tau protein
A673V mutation
Familial AD
Aβ1–6A2V(D) peptide
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824005085
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