Decreased Expression of the EAAT5 Glutamate Transporter at Photoreceptor Synapses in Early, Pre-Clinical Experimental Autoimmune Encephalomyelitis, a Mouse Model of Multiple Sclerosis

Decreased Expression of the EAAT5 Glutamate Transporter at Photoreceptor Synapses in Early, Pre-Clinical Experimental Autoimmune Encephalomyelitis, a Mouse Model of Multiple Sclerosis

Background: Multiple sclerosis is a frequent neuroinflammatory and neurodegenerative disease of the central nervous system that includes alterations in the white and gray matter of the brain. The visual system is frequently affected in multiple sclerosis. Glutamate excitotoxicity might play a role i...

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Bibliographic Details
Main Authors: Ali El Samad, Julia Jaffal, Dalia R. Ibrahim, Karin Schwarz, Frank Schmitz
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomedicines
Subjects:
multiple sclerosis
EAE
retina
photoreceptor synapse
EAAT5 (SLC1A7)
glutamate transporter
Online Access:https://www.mdpi.com/2227-9059/12/11/2545
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