Safety and efficacy of oral administrated cepharanthine in non-hospitalized, asymptomatic or mild COVID-19 patients: a Double-blind, randomized, placebo-controlled trial

Safety and efficacy of oral administrated cepharanthine in non-hospitalized, asymptomatic or mild COVID-19 patients: a Double-blind, randomized, placebo-controlled trial

Abstract Cepharanthine (CEP) is a natural remedy that potently inhibits SARS-CoV-2 activity both in vitro and in vivo. To evaluate the efficacy and safety of CEP compared with placebo in adults with asymptomatic or mild coronavirus disease 2019 (COVID-19), we conducted a proof-of-concept, double-bli...

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Main Authors: Jianyi Wei, Shupeng Liu, Yuexiang Bian, Lei Li, Biyun Qian, Zixuan Shen, Yan Zhang, Adila Abuduaini, Fuchen Dong, Xin Zhang, Jinhui Li, Yongpei Yu, Weituo Zhang, Jun Wang, Wei Zhai, Qixiang Song, Yu Zheng, Weihua Pan, Lanlan Yu, Qimin Zhan, Ning Zhang, Junhua Zheng, Shuming Pan, Chen Yao, Hai Li
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Cepharanthine
COVID-19
Effectiveness
Safety
SARS-CoV-2
Online Access:https://doi.org/10.1038/s41598-024-75891-3
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