A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) Vahl
Ficus hirta Vahl, a member of the Moraceae family and genus Ficus, is a traditional medicinal plant with diverse metabolites. Traditionally, Ficus hirta Vahl has been used in Asian countries to treat various ailments including indigestion, loss of appetite, cold, pneumonia, tuberculosis, cough, asth...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545348/full |
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| author | Minghui Chen Jiao Liu Sihua Zou Jingquan Yuan Jiyu Pan Zhenmei Lin Yanchun Wu Yanchun Wu Bei Zhou Bei Zhou |
| author_facet | Minghui Chen Jiao Liu Sihua Zou Jingquan Yuan Jiyu Pan Zhenmei Lin Yanchun Wu Yanchun Wu Bei Zhou Bei Zhou |
| author_sort | Minghui Chen |
| collection | DOAJ |
| description | Ficus hirta Vahl, a member of the Moraceae family and genus Ficus, is a traditional medicinal plant with diverse metabolites. Traditionally, Ficus hirta Vahl has been used in Asian countries to treat various ailments including indigestion, loss of appetite, cold, pneumonia, tuberculosis, cough, asthma, excessive sweating, backache, bruises, arthritis, liver diseases, skin conditions, gynecological disorders, and pediatric illnesses. As a botanical drug with both medicinal and nutritional applications, Ficus hirta Vahl is an integral part of China’s multi-ethnic medical system, serving as a tonic for many years. Approximately 130 chemical metabolites have been identified from Ficus hirta Vahl to date, including flavonoids, phenylpropanoids, phenolics, phenol glycosides, terpenoids, sterols, quinones, and esters. The bioactive properties of Ficus hirta Vahl extracts include immune modulation, enhancement of digestive system function, antitussive and antiasthmatic effects, as well as antibacterial, anti-inflammatory, antioxidant, anti-aging, hepatoprotective, anti-radiation, and antitumor activities. Toxicological assessments confirmed the safety and nontoxicity of Ficus hirta Vahl A thorough review of the literature underscores the significant potential of Ficus hirta Vahl across multiple domains such as medicine, food, and agriculture. However, research on Ficus hirta Vahl remains limited, necessitating further investigation into its pharmacokinetics and mechanisms of action. |
| format | Article |
| id | doaj-art-8f7aa1a8b54341e3bf0d77836a20f32b |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-8f7aa1a8b54341e3bf0d77836a20f32b2025-08-20T03:52:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15453481545348A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) VahlMinghui Chen0Jiao Liu1Sihua Zou2Jingquan Yuan3Jiyu Pan4Zhenmei Lin5Yanchun Wu6Yanchun Wu7Bei Zhou8Bei Zhou9Guangxi University of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaGuangxi Key Laboratory of Efficacy Study on Chinese Materia Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaGuangxi Key Laboratory of Efficacy Study on Chinese Materia Medicine, Nanning, ChinaFicus hirta Vahl, a member of the Moraceae family and genus Ficus, is a traditional medicinal plant with diverse metabolites. Traditionally, Ficus hirta Vahl has been used in Asian countries to treat various ailments including indigestion, loss of appetite, cold, pneumonia, tuberculosis, cough, asthma, excessive sweating, backache, bruises, arthritis, liver diseases, skin conditions, gynecological disorders, and pediatric illnesses. As a botanical drug with both medicinal and nutritional applications, Ficus hirta Vahl is an integral part of China’s multi-ethnic medical system, serving as a tonic for many years. Approximately 130 chemical metabolites have been identified from Ficus hirta Vahl to date, including flavonoids, phenylpropanoids, phenolics, phenol glycosides, terpenoids, sterols, quinones, and esters. The bioactive properties of Ficus hirta Vahl extracts include immune modulation, enhancement of digestive system function, antitussive and antiasthmatic effects, as well as antibacterial, anti-inflammatory, antioxidant, anti-aging, hepatoprotective, anti-radiation, and antitumor activities. Toxicological assessments confirmed the safety and nontoxicity of Ficus hirta Vahl A thorough review of the literature underscores the significant potential of Ficus hirta Vahl across multiple domains such as medicine, food, and agriculture. However, research on Ficus hirta Vahl remains limited, necessitating further investigation into its pharmacokinetics and mechanisms of action.https://www.frontiersin.org/articles/10.3389/fphar.2025.1545348/fullFicus hirta (Moraceae) Vahlbotanical characterizationtraditional medicinephytochemistrypharmacologytoxicology |
| spellingShingle | Minghui Chen Jiao Liu Sihua Zou Jingquan Yuan Jiyu Pan Zhenmei Lin Yanchun Wu Yanchun Wu Bei Zhou Bei Zhou A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) Vahl Frontiers in Pharmacology Ficus hirta (Moraceae) Vahl botanical characterization traditional medicine phytochemistry pharmacology toxicology |
| title | A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) Vahl |
| title_full | A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) Vahl |
| title_fullStr | A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) Vahl |
| title_full_unstemmed | A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) Vahl |
| title_short | A review on the ethnopharmacology, metabolites, pharmacological uses, and toxicology of Ficus hirta (Moraceae) Vahl |
| title_sort | review on the ethnopharmacology metabolites pharmacological uses and toxicology of ficus hirta moraceae vahl |
| topic | Ficus hirta (Moraceae) Vahl botanical characterization traditional medicine phytochemistry pharmacology toxicology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545348/full |
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