Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma

Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma

Advanced colorectal carcinoma is currently incurable, and new therapies are urgently needed. We report that phosphotyrosine‐dependent Eph receptor signaling sustains colorectal carcinoma cell survival, thereby uncovering a survival pathway active in colorectal carcinoma cells. We find that genetic a...

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Main Authors: Michael DiPrima, Dunrui Wang, Alix Tröster, Dragan Maric, Nekane Terrades‐Garcia, Taekyu Ha, Hyeongil Kwak, David Sanchez‐Martin, Denis Kudlinzki, Harald Schwalbe, Giovanna Tosato
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Molecular Oncology
Subjects:
cell death
colorectal cancer
Eph receptors
Ephrin ligand
tyrosine kinase signaling
Online Access:https://doi.org/10.1002/1878-0261.12576
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https://doi.org/10.1002/1878-0261.12576

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