Lipid discovery enabled by sequence statistics and machine learning

Lipid discovery enabled by sequence statistics and machine learning

Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified that Streptococcus agalactiae MprF synthesizes lysyl-phosphatidylglycerol (Lys-PG) from anion...

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Bibliographic Details
Main Authors: Priya M Christensen, Jonathan Martin, Aparna Uppuluri, Luke R Joyce, Yahan Wei, Ziqiang Guan, Faruck Morcos, Kelli L Palmer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
Enterococcus faecalis
Streptococcus agalactiae
MprF
restricted Boltzmann machine
lipid membrane
enzyme specificity
Online Access:https://elifesciences.org/articles/94929
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https://elifesciences.org/articles/94929

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